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For example, the IV drug gentamicin, which is cleared through the kidneys, has a half-life of 2-3 hours in a young person with no kidney disease, but its half-life is over 24 hours in somebody with severe kidney disease

Imai Y, Kuba K, Neely GG et al (2008) Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

Neurochem Int 56:611619 Karunakaran D, Diwakar L, Saeed U, Agarwal V, Ramikrishnan S, Iyengar S et al (2007) Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinsons disease: protection by alpha lipoic acid

Carotenoids and retinoids: nomenclature, chemistry, and analysis, in The Biochemistry of Retinoid Signaling II