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The exploratory objective is to assess changes in Lyme specific labs including the standard immunoblot and the T-cell based Elispot as well as the CD57+ lymphocyte immune marker

doi: 10.1111/jdi.13164 221 KonariNNagaishiKKikuchiSFujimiyaM

Further, loss in SAH-hydrolytic and decrease in SAH-synthetic activity by H363A mutation strengthens the earlier structural observation, where His363 needs to flip out in order to accommodate ethylthioadenosine (ETA, a partial analog of SAH) 12