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Thirty days after the second dose, K18-hACE2 or K18-hACE2/B-KO mice were challenged intranasally with 5 10 4 PFU of SARS-CoV-2 (for the Wuhan strain, Delta and Omicron variant) and 5 10 3 PFU of SARS-CoV-2 (for the Gamma variant)