In the situation of I/R injury, NSAIDs have been shown to attenuate the production of pro-inflammatory cytokines (e.g., TNF- , IL-6) and reduce microglial activation, which are key drivers of neuroinflammation (Ajmone-Cat et al., 2010)
Funding This work was supported by the National Nature Science Foundation of China (81902162, U21A20347), the Swedish Research Council (2018-02267), Swedish governmental grants to scientists working in healthcare (ALFGBG-965197), the Henan Provincial Science and Technology Department (222102310161, 182102310688, 202102310221), and the Henan Province Medical Research Project (LHGJ20190349)

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