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While clinical evidence remains limited, both peptides may have potential applications in supporting chondrocyte viability and potentially attenuating cartilage degradation processes associated with osteoarthritic conditions

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Highlights GDC temporarily decreases TEER in Caco-2/HT29-MTX monolayers, without cytotoxicity GDC decreases OCLN fluorescence intensity and increases lactulose paracellular transport GDC increases acidic mucins production and decreases intracellular cAMP GDC treated monolayers are biocompatible with Infant Formula digesta 1 Introduction The infant gut barrier has a higher paracellular permeability during early development ( There are ethical and logistical challenges of conducting clinical trials in early infancy to understand the gut barrier