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2 Mechanisms of ferroptosis in ocular tissues 2.1 Dynamic balance of GSH and GPX4 In tissues rich in polyunsaturated fatty acids (PUFAs), such as the retina (13), the GSH-GPX4 axis maintains membrane stability by scavenging phospholipid hydroperoxides (PL-OOH)

Additionally, pathway enrichment analysis further revealed that these alterations corresponded to disruptions in key metabolic routes, including the glucose-alanine cycle, glucose metabolism, beta-oxidation of very long-chain fatty acids, glutathione metabolism, transfer of acetyl groups into mitochondria, and the degradation pathways of branched-chain aminoacids (BCAA) (Figure S3)

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