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In conjunction with her other nutritional tests, this organic acids tests also highlighted a potential issue with her vitamin B6 pathway, given her low B6 marker and low phosphoric acid

10.1016/j.jad.2024.01.080 40 HumphreysK

76 Also, with some Class I variants the oxidation of membrane sulfhydryl groups leads to the accumulation of membrane polypeptide aggregates, presumably due to disulfide bond formation between spectrin dimers and other membrane proteins