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While these cardiovascular applications fall outside typical research use, they demonstrate the peptide's fundamental ability to promote vascularization across different tissue types

doi: 10.1016/j.bcp.2011.09.029 256

Toxicology 278(1):5567 Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS, Slominski AT (2012) Melatonin membrane receptors in peripheral tissues: distribution and functions

Nevertheless, amides can undergo chemical reactions, usually through an attack of an electronegative atom on the carbonyl carbon, breaking the carbonyl double bond and forming a tetrahedral intermediate