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(4) p53 drives miR34c expression to promote apoptosis by inhibiting the activity of the antiapoptotic genes Bcl-2 or c-Myc (88)

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The second clinical study on Protandim was double-blinded, randomized and placebo-controlled, making the results more reliable, although it was quite brief just 7 days

Some studies have reported no significant differences in IGF-1 levels or side effects following interventions such as lycopene supplementation or calorie restriction, suggesting a lack of direct effect in certain cases