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And when that happens, the results can be deadly

The methylation cycle works through several key steps: Folate turns into 5-methyltetrahydrofolate (5-methylTHF), the form that flows in blood to create methionine [16] Methionine then makes SAM, which gives methyl groups to DNA, RNA, protein, and neurotransmitter methylation [15] After giving methyl groups, SAM becomes S-adenosylhomocysteine (SAH) and then homocysteine [15] The cycle keeps going as folate helps turn homocysteine back to methionine [1] This methylation cycle shows how genetics shapes epigenetics perfectly [17]

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Total B12 concentration in serum is most frequently used, despite its poor sensitivity and specificity