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Notably, we further observed that intervention with L-732138 significantly facilitated the expression of proinflammatory cytokines whereas down-regulated the anti-inflammatory cytokines

doi: 10.3389/fimmu.2025.1703672 Received 12 September 2025 Accepted 17 October 2025 Published 31 October 2025 Volume 16 - 2025 Edited by Kosuke Nishi, Ehime University, Japan Reviewed by Abdullah Shaito, Qatar University, Qatar Rezvan Yazdian-Robati, Mazandaran University of Medical Sciences, Iran Updates Copyright 2025 Liu and Jiao

The concept of trained immunity-based vaccines (TIbV), proposed by Snchez-Ramn et al

Fixed cells were then washed in PBS and incubated with 50 mM NH4Cl/PBS for 15 min at room temperature