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In addition, it remains very uncertain whether gut microbiome is a causative factor or a consequence of the disease, which necessitates more thoughtful approaches, including colonization of germ-free mice with gut microbiome associated with the disease which might offer more insight into the role of these bacteria in the disease pathogenesis

HGF is a potent neurotrophic factor that promotes neurogenesis and has been shown to have neuroprotective effects in neurodegenerative diseases (reviewed in: 37 )

The mutations of IDH1 or IDH2 exhibit a neomorphic activity by converting glutaminederived KG to 2hydroxyglutarate (2HG), which competitively inhibits KGdependent histone and DNA demethylases (Dang et al , 2010

Illness and infection can accelerate muscle breakdown, making amino acid availability important for maintaining muscle mass