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Thus, the causal relationship among ER stress induction, pERK1/2, and autophagy activation was examined using MAPK/ERK and ER stress inhibitors, namely U0126 and 4-PBA

In parallel, injection of anti-ACBP mAb into Alms1 -/- mice caused a decrease in organ weight, adipocyte size, liver and brown adipose tissue lipid content (Fig