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In summary, the discovery of ferroptosis expands our understanding of CD in CCVDs, and targeting ferroptosis will provide a new strategy and broaden thoughts for the prevention and treatment of CCVDs

Moreover, ovarian aging is associated with an increased risk for diabetes, heart disease, cancer, and other age-related conditions

The other main roles of arhalofenate are to activate AMPK, inhibit NF-B and NLRP3 inflammasomes to promote the polarisation of anti-inflammatory macrophages, as well as significantly reduce UA-induced inflammation (Salminen et al., 2011

The findings indicated that radiation long, term altered the overall gut microbial composition, therefore, favouring harmful species such as Erysipelotrichaceae and Akkermansia muciniphila while decreasing beneficial bacteria such as Firmicutes and Actinobacteria