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These findings indicate that the inactivation of AKT2 stimulates MEK1/2 activity in colon cancer cells resistant to IGF-1R inhibition

Interestingly, Boehmes research revealed early PASMC overproliferation in pulmonary overcirculation, characterized by a unique metabolic profile independent of HIF-1, PDHK1, or increased glycolytic flux [213]

In this blog post, we take the approach of going back to what is known (and is NOT known) about the biochemical basics of this molecule to give context to the sometimes confusing smorgasbord of proposed applications for procalcitonin testing that exists in the literature