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doi: 10.1038/s41565-023-01346-x

The 12-week placebo-controlled trial did not reach its primary endpoints, but the 36-week open-label extension trial showed significant improvements in 6-minute walk distance (+95.9 m, p=0.024), symptom scores, and knee extensor muscle strength

140 Conversely, poor sleep can change the composition of the gut microbiome, which may contribute to metabolic disturbance and immune, neurologic, and hormonal dysregulation

As an antioxidant and free radical scavenger, NAC boosts intracellular GSH at the cellular level, which is crucial for combating neurodegenerative diseases and neuronal death caused by oxidative stress (Vargas-Barona et al., 2024