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Based on these findings, the inclusion of immunonutrients in the diet of RA patients could be an alternative to improve some disease conditions such as pain alleviation, reduced count of tender joints, and shortening of the morning stiffness duration, which can also influence on the attenuation of the disease clinical activity [6]

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Accordingly, any factors that restrict the migration of these stem-like CD8 + T cells from TdLNs into tumor sites presumably constitute a critical barrier for resistance to cancer immunotherapy, including dysregulated chemokine signaling, vascular barriers, and physical stromal obstacles