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The Phase IIb efficacy trials did not meet their efficacy endpoints, and clinical development for the original therapeutic indication was halted

Keio J Med

Structurally, Tf consists of two lobes [94], and each binds a single Fe ion, resulting in three possible iron occupancy states: binding one Fe 3+ , binding two Fe 3+ (holo-Tf), and binding none Fe 3+ (apo-Tf) [85]

Epidermal Growth Factor Receptor (EGFR) is required for cell survival in the Drosophila eye disc, where it inhibits the pro-apoptotic gene hid 73,74,75