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Next, the protein domains detected between different groups were analyzed ( Fig

Studies on IPF lung samples showed increased staining of the ER stress- and UPR activation-associated proteins ER chaperone immunoglobulin heavy-chain-binding protein (BiP), X-box-binding protein 1 (XBP-1), and ER degradation enhancing -mannosidase-like protein (EDEM) in epithelial cells, in comparison with healthy control lung tissues [214]