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Regions are defined as belonging to one of four genetic context categories: genomic tiling (5000 bp genomic windows with dense probe coverage), CpG islands (Ensembl annotations), gene promoters (1.5 kb upstream and 0.5 kb downstream of transcription start sites), and genes (whole loci from transcription start sites to transcription end sites) [101]

[18] SSRIs, which mainly regulate serotonin, subsequently replaced tricyclics as the primary treatment option for depression because of their better tolerability and lower incidence of adverse effects

Finally, a 2017 Cochrane systematic review and meta-analysis of 20 randomized controlled trials reported a small benefit of omega-3 supplementation on depressive symptoms when compared to placebo, yet the evidence was deemed of very low quality and the positive effect was judged likely to be biased and not clinically significant (195)

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