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Following an acute administration of EtOH (5 g/kg, i.p.), KO animals exhibited 30% and 50% less EtOH and AA accumulation in circulation, respectively, suggesting an increased capacity for liver EtOH and AA metabolism in KO mice

Approximately 1% of most of the worlds populations is affected by CeD, while HLA-DQ2 and HLA-DQ8 occur in most affected populations, suggesting that a spectrum of other, environmental and genetic factors contribute to CeD manifestation

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