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No studies were identified evaluating GHK-Cu exposure in patients undergoing TJA or other major orthopaedic procedures

This lack of effect on stress hormones was evident even at doses more than 200-fold higher than the ED50 for growth hormone release, establishing ipamorelin as the first GHRP-receptor agonist with selectivity for growth hormone release similar to GHRH itself

Based on the aforementioned phase-2 clinical trial results, the compound was included in phase-3 trials which investigated its potential to prevent muscle wasting in patients with advanced lung cancer

Akt can also activate mTOR and p70S6 kinase to stabilize beta-catenin to enhance proliferation (21)