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For instance, Z-Arg-Arg-p-nitroaniline, Bz-Phe-Val-Arg-pNA, p Glu-Phe-Leu- p -nitroanilide and N-Cbz-L-Gln- p -nitrophenyl ester hydrolysis leads in solution to chromophores easy detectable at 405 nm ( 4 Bromelain as an emerging anticancer agent: Molecular mechanisms, signaling pathways and therapeutic targets To elucidate in detail the potential mechanisms of anticancer action, bromelain has been extensively studied in numerous studies ( in vivo in animal models and in vitro as a potential agent against several cancer lines such as gastrointestinal, colorectal, breast, mesothelioma, lung, hepatic, pancreatic, epidermoid, and melanoma ( Table 2 and Figure 1 )

GSH, the most abundant antioxidant in the heart, plays a fundamental role in normalizing a redox homeostatic mechanism that was shifted toward oxidative or reductive stress

However, contrasting evidences suggest that the timing of phosphorylation is crucial in governing both the initiation nucleation and fibrillation process