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It can be irritating Helps stabilize the product formulation Used to adjust the product's pH An emollient that softens the skin and forms a protective layer on its surface

There have been no reported cases of encapsulated meningococcal infections in any adults with PNH treated with pegcetacoplan, as of 11/13/2025

In addition, ALOX12/15 is able to disrupt DC maturation and activation through the NRF2 pathway in inflammatory models, but the mechanism by which it elicits antitumor immune dysfunction in DCs remains uncertain in TME [125]