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Peer-reviewed case reports document serious adverse events attributed to unsupervised, non-research self-administration of melanotan analogs, including melanoma cases reported in association with concurrent ultraviolet exposure (Hjuler & Lorentzen, Dermatology 228:346, 2014, PMID 24355990

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A double-blind, randomized, placebo-controlled, pilot clinical trial examining buspirone as an adjunctive medication during buprenorphine-assisted supervised opioid withdrawal