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Approval was obtained from the institutional review board of the University Hospital Cologne (approval Number: 15-031) and the trial was registered on clinicaltrials.gov (NCT02745444, Registration date: 15 April 2016) as well as the German Register for Clinical Trials (DRKS00007704, Registration date: 14 October 2015)

Specifically, DDR2 interacted with Src kinase, leading to the nuclear translocation of homologous transcriptional regulators (yes-associated protein 1 [YAP1] and WW domain containing transcription regulator 1 [WWTR1]) of the Hippo pathway, which altered the expression level of ferroptosis-related genes

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