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In the initial phase, robust T-cell responses selectively eliminate tumor cells expressing the targeted neoantigens, creating immunologic pressure that shapes tumor evolution

So there's people that have SNPs in heat shock protein factor 70, that if they have one of them, so they got one from their parents where they have more active heat shock protein 70, they live on average one year longer than people that don't have that SNP

Microneedling combined with topical GHK-Cu is another approach, creating tiny channels through the stratum corneum that allow the peptide to reach the dermis