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When determining the Alanine to Lysine ratio as an indirect measure of mitochondrial distress we found that unaffected children had an average ratio of 5.8 and those with konzo have an average ratio of 6.9, both of which are substantially higher than the expected ratio of less than 3 for healthy adolescents (Fig

Together, we will explore nuances like optimal timing for supplementation, ideal dosages, forms of intake, and lifestyle practices that support their effectiveness

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This results in loss of membrane stability and deformability of the RBC, giving the cell its spherical shape (spherocyte)