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This "cellular cleanup" mechanism is vital for reducing the oxidative stress and neuroinflammation that contribute to the cognitive dysfunction, or "brain fog," so frequently reported in Long COVID

Flanigan TJ, Anderson JE, Elayan I, Allen AR, Ferguson SA (2018) Effects of Cyclophosphamide and/or Doxorubicin in a Murine Model of Postchemotherapy Cognitive Impairment

In summary, TAN is involved in the ferroptosis molecular network through multiple pathways such as NETosis, MPO delivery, and iron metabolism regulation

The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE 80 partner repository with the dataset identifier PXD078525