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One of the key questions at this point, as Jerne explained, was whether 'the mouse contains a small number of pre-committed cells that are the only cells that can respond to a given antigen, or the mouse contains a small number of pre-formed antibody molecules of a certain type that have to attach to the antigen as a first step toward antibody formation' (Jerne, 1966)

Prior to deep learning, most studies use rules (regular expressions, logic expressions, and keywords) with feature engineering methods for text classification 8,13

[8] Ladurner G, Kalvach P, Moessler H

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