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The mechanistic case is strong and the symptom relief is often real : dehydration and electrolyte loss explain much of how a hangover feels, IV fluids correct both directly and immediately, and antiemetic and anti-inflammatory add-ons target nausea and headache that genuinely respond to those agents

Samples of human tissue from knee replacement surgeries which include both the extracellular scaffolding, or matrix, in the joint as well as cartilage-generating chondrocyte cells also responded to the treatment by making new, functional cartilage

Thromb Haemost 109:10991107

doi: 10.1523/jneurosci.19-02-00562.1999 203