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Therefore, based on the experimental results, we speculated that pretreatment of BSP1 significantly reversed the decrease in Nrf2 / Keap1 induced by p31-43, it can promote the expression of Nrf2 downstream antioxidant enzyme gene, protect the activity of the antioxidant enzyme (CAT, GR, and GST), and accelerate the efficiency of cell biosynthesis of GSH by promoting the expression of GCLC and GCLM, and relieve the oxidative stress of cells by p31-43

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Reprogramming of Cellular Metabolism and Its Therapeutic Applications in Thyroid Cancer