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10.1016/j.canlet.2024.217089 2 AntonelliA.BattagliaA

Kidney disease: Impaired renal function reduces B12 clearance, leading to accumulation

Zhou et al., 2018), oxidative stress responses and mitochondrial dysfunction (Xia et al., 2018), endoplasmic reticulum stress responses (Yu et al., 2020), and abnormalities in amino acid metabolism (Zhang et al., 2018)

In vivo , inhibition of NOX activity using pharmacological agents such as apocynin or VAS2870 has been shown to attenuate tissue inflammation, reduce collagen fragmentation, and improve histological repair in animal models (Reis et al., 2020