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Mitochondrial uptake of calcium in response to excitotoxic glutamate stimulation leads to ROS production (Castilho et al., 1999)excessive opening of the mitochondrial membrane permeability transition pore leads to a decrease in mitochondrial membrane potential (Castilho et al., 1999), induction of neuronal death (Stout et al., 1998

The confusion matrixes reveal that these differences in quality of NT identification are related to different ability to discriminate among non-catecholamine neurotransmitters (serotonin, GABA, acetylcholine) depending on the type of fluorescence response under consideration (Fig

Its receptor signaling is considered a key mediator by regulating tight junction proteins and maintaining the homeostasis of brain ECs function to affect BBB permeability (Bynoe et al., 2015