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In vitro and in vivo studies have shown that genetic and pharmacological inhibition of USP14 induces degradation of an androgen receptor (AR), favoring tumor suppression in AR-positive breast cancer cells or prostate cancer cells (Liao et al., 2017

Gohar 2019

However, there are no available probes designed for targeting and purifying peptides/proteins containing irreversible Oxi-Cys ( S -O 3 H), but a few for S -O 2 H, such as the DiaAlk probe have been developed (Figure 5B)