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Initial analysis of our RNA-seq dataset comparing melatonin- and vehicle-treated ILC2s revealed broad suppression of pro-inflammatory gene expression following melatonin treatment, including canonical type 2 cytokines such as Il5 , Il13 , and Csf2

By 3 days post-ischemia, astrocytes exhibit strong reactive phenotypes, including high inducible nitric oxide synthase (iNOS) expression and pronounced morphological changes

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