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Mechanistic studies showed that GPX4 expression and ferrous iron were increased in 5-FU and AZ628-derived CRC persister cells, residual subcutaneous transplantation tumors, and colorectal cancer patients undergoing neoadjuvant chemoradiotherapy

The sulfhydryl (-SH) group of cysteine is crucial for protein function, enabling catalysis, redox regulation via disulfide bonds, and metal binding in metalloproteins [35]