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Further research found that GA can reverse the decline of peroxisome proliferator-activated receptor alpha (PPAR-) and liver X receptor-alpha (LXR-) and the increase of sterol regulatory element-binding protein-1c (SREBP-1c) mRNA caused by HFD by anti-oxidative stress and improving steatopathy, thus alleviating NAFLD (Chen et al., 2011)

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Accordingly, in patient hepatocarcinoma samples, miR-377-3p levels are inversely correlated with CPT1C expression and predict clinical outcomes

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Thus, to gather additional evidence about the identity of the LDOX oxidation product, we performed enzymatic reactions in buffer containing H 2 18 O, exploiting the expected equilibrium between the gem-diol flavan-3,3,4-triol ( 4 ) and the corresponding ketone flavan-3-on-4-ol ( 7 ) (Fig