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The sensitizing RT-RDT effects of TZM can promote the up-regulation of cGAS-STING pathway and PD-L1 expression by inducing ICD of cancer cell, thus triggering a powerful anti-tumor immune response

Recipient comorbidities: Patients with NASH-related cirrhosis often present with multiple comorbid conditions, including obesity, cardiovascular disease, type 2 diabetes, and chronic kidney disease, all of which complicate perioperative management and impact post-transplant outcomes [123, 130]

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Moreover, this research has provided significant findings on the changes in gene expression inside Sertoli cells with genes involved in metabolite interconversion enzymes