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It is important to note that most current insights into autophagy are based on the detection of autophagy-related factors, and accurately quantifying autophagic flux remains a significant challenge

Characterization of symptoms and symptom clusters for type 2 diabetes using a large Nationwide Electronic Health Record Database

Future studies should incorporate mechanism-relevant biological markers, including serum BDNF to index neurotrophic signaling, inflammatory markers such as CRP and IL-6, measures of HPA-axis activity such as the cortisol awakening response, and neuroimaging markers (e.g., fMRI-based assessments of hippocampal connectivity), to more precisely characterize treatment response and patient stratification

Marmelosin also mitigates dyslipidemia by lowering triglycerides and total cholesterol while increasing HDL cholesterol, which may contribute to improved metabolic control and reduced cardiovascular risk