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Furthermore, this phenomenon is exclusive for VPA as treatment with other anticonvulsants, such as carbamazepine or lamotrigine did not trigger alteration in the expression of SCN3A

The bloodbrain barrier (BBB) with its tight junctions, membrane transporters, receptors and metabolizing enzymes is a main player in drug delivery to the brain, restricting the entrance of the drugs and other xenobiotics

In PubMed, a representative Boolean search structure was constructed based on controlled vocabulary and free-text terms and modified to suit the other databases