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identified a metastasis-associated fibroblast subtype, tryptophan 2,3-dioxygenase-positive matrix fibroblasts (TDO2 + MFs), which secret kynurenine to upregulate ferritin heavy chain 1 expression in DTCs, enabling DTCs to resist ferroptosis and inducing T cell dysfunction [52]

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379,448 The possible mechanisms include the activation of cAMP response element binding protein (CREB) in the hippocampus and canonical neuroprotective mechanisms

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