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Research in PD animal models has shown that NPT200-11 reduces abnormal -syn accumulation, suppresses astrocytic activationthus attenuating neuroinflammationand normalizes striatal dopamine transporter (DAT) levels, alleviating motor deficits in PD mice [155]

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Ferroptosis, an iron-dependent regulated cell death (RCD) mechanism involving lipid peroxidation and glutathione (GSH) depletion, exhibits unique features distinct from other RCD forms (e.g., apoptosis, necrosis, and pyroptosis)