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En 1980, Rebouche y Engel fueron los primeros en dilucidar el mecanismo y el proceso de sntesis de la L-carnitina en los organismos vivos, dividindolo en tres pasos y seis factores esenciales: L-lisina, metionina, Niacina , Vitamina C , vitamina B6, hierro, entre los cuales la L-lisina constituye el esqueleto para la sntesis de la L-carnitina