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(Thompson et al., 2019), glutarate hydroxylase, also known as glutarate dioxygenase (EC 1.14.11.64), uses molecular oxygen to hydroxylate glutarate to l-2HG with concomitant decarboxylation of 2-oxoglutarate to succinate

Vitamin B6 occurs as an alcohol (pyridoxine), an aldehyde (pyridoxal), and an amine (pyridoxamine)

Because glutathione has a relatively short halflife (on the order of minutes in circulation) and oral glutathione is broken down in the gut and at cell surfaces, IV delivery is often used to bypass these absorption limitations and achieve higher shortterm plasma levels

147 published a randomized trial in which the melatonin/hypothermia group, at 5 days of life, had fewer seizures and fewer white matter abnormalities on MRI