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Osterlund E, Maddalena G, Pellatt AJ, Vetere G, Eluri M, Parseghian C, Aziz KE, Alfaro K, Kell RJ, Konishi T, Overman MJ, Morelli MP, Willis J, Shen J, Raghav K, Newhook T, Shen X, Morris V, Dasari NA, Kopetz S

This chronic inflammation subsequently promotes the development of reactive stroma, a fibrotic ECM structure enriched with activated CAFs and an overproduction of ECM proteins

The motheaten phenotype is due to a splicing mutation in SHP1 causing an absence of detectable protein and mice that have severe disorders of hematopoietic cells resulting in death within 3 weeks after birth (148)

This occurs when there's an imbalance between the generation and buildup of reactive oxygen species (ROS) within cells and tissues and the ability of innate biological systems and dietary antioxidants to eliminate these reactive byproducts