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These protocols help clinicians balance efficacy with safety, reducing the risk of severe complications while maintaining therapeutic intent

Published phase 3 trials including OASIS 1 (Knop et al., 2023) show that even low absolute bioavailability can be clinically meaningful if the drug is potent enough and the dose is calibrated accordingly

This mechanism helps counteract the adaptive reduction in metabolic rate that often accompanies weight loss, a common limitation of appetite-focused therapies