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3 Biomedical Research Institute, Lifeliver Co Ltd, Yongin, Korea, Republic of Background: Severe aplastic anemia (SAA) is a rare and potentially fatal disease that is characterized by an immune-mediated functional impairment of hematopoietic stem cells (HSCT), with peripheral blood stem cell transplantation (PBSCT) or bone marrow transplantation (BMT), is the treatment of choice for young patients who have a matched related donor (MRD)

15,16 Therefore, a balance exists in how folate is distributed between these two metabolic pathways, with competition for the 5,10-methyleneTHF cofactor existing at the nexus of these pathways

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