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94 , 95 Furthermore, tumor cells have more abundant microvilli on their cell surface in comparison with normal cells, and the increased overall surface area of tumor cells allows a greater number of AMP molecules to interact with the surface of cancer cells, thereby promoting AMP-mediated cytotoxicity

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In the undercurrent study, abemaciclib induced a distinct diminution in the expression of the PI3K/AKT/mTOR pathway and CDK4, CDK6, and TGF-1/NF- in MCF-7 and MDA-MB-231 cell lines, whereas the expression of the PI3K/AKT/mTOR pathway, CDK4, CDK6, and TGF-b1/NF- was more decreased by the grouping of abemaciclib and IRR (10 Gy)