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While serotonins exact role in depression is still being debated, low serotonin levels have traditionally been linked to symptoms such as sadness, low energy, and irritability all of which are often seen in people with major depressive disorder

ARA-290 interacts with the innate repair receptor (IRR), making it a promising candidate in research related to chronic inflammation, neuropathic pain, and autoimmune conditions

An epidural injection may be given using any one of the following approaches: Transforaminal route: This technique allows precise administration of the steroid solution into the epidural space, near the area where the nerve is likely to be irritated